Pair Name	Parthenolide, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Overexpression of both Nrf2 and its target activities
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	HSPA4	hsa3308
	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	SOD2	hsa6648
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	PN prevented the acquisition of resistance induced by Mitox and DOX treatment in MDA-MB231 cells. This effect was mediated by inhibition of overexpression of both Nrf2 and its target activities. Therefore, within MDA-MB231 cell lines, PN not only exerts toxic effects on stem-like cells, which are responsible for tumour recurrence, but also prevents drug resistance